NBI 35965 hydrochloride

Cat. No. 3100 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective CRF₁ antagonist

化学名： (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for NBI 35965 hydrochloride

NBI 35965 hydrochloride is a potent and selective corticotropin-releasing factor receptor 1 (CRF₁) antagonist (K_i values are 4 and > 10000 nM at CRF₁ and CRF₂ respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC₅₀ values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.

化合物库 for NBI 35965 hydrochloride

NBI 35965 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NBI 35965 hydrochloride

分子量	437.79
公式	C₂₁H₂₂Cl₂N₄.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1782228-59-4
PubChem ID	71433630
InChI Key	LNYUWBPFYXPUIO-RSAXXLAASA-N
Smiles	CC[C@@H]3N(CC5CC5)C1=C2C(C(C4=CC=C(Cl)C=C4Cl)=NN2C3)=NC(C)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NBI 35965 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	43.78	100
	DMSO	43.78	100

制备储备液 for NBI 35965 hydrochloride

以下数据基于产品分子量 437.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.42 mL	22.84 mL
5 mM	0.46 mL	2.28 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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产品说明书 for NBI 35965 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NBI 35965 hydrochloride

参考文献是支持产品生物活性的出版物。

Million et al (2003) A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res. 985 32 PMID: 12957366

Hoare et al (2003) Mechanism of corticotropin-releasing factor type I receptor regulation by non-peptide antagonists. Mol.Pharmacol. 63 751 PMID: 12606786

Gross et al (2005) Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists. J.Med.Chem. 48 5780 PMID: 16134945

If you know of a relevant reference for NBI 35965 hydrochloride, please let us know.

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关键词: NBI 35965 hydrochloride, NBI 35965 hydrochloride supplier, NBI35965, CRF1R, CRF, 1, receptor, antagonist, corticotropin-releasing, factor, antagonists, CRF1, Receptors, 3100, Tocris Bioscience

2 篇 NBI 35965 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NBI 35965 hydrochloride 的部分引用包括：

Abdelhamid et al (2013) Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors. Neuropharmacology 72 29 PMID: 23624287

Martinon and Dabrowska (2018) Corticotropin-Releasing Factor Receptors Modulate OXT Release in the Dorsolateral Bed Nucleus of the Stria Terminalis (BNST) in Male Rats. Front Neurosci 12 183 PMID: 29618970

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