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NCT 02

Cat. No. 7551 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Molecular glue; induces degradation of CCNK and CDK12
化学名： 6,7-Dihydro-N-(5-methyl-2-thiazolyl)-5H-indeno[5,6-b]furan-3-acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NCT 02

NCT 02 acts as a molecular glue that induces proteasomal degradation of CCNK and CDK12 in colorectal cancer spheroid cells in vitro (IC50 ≤ 50 μM). NCT 02 also induces apoptosis and the downregulation of genes involved in DNA damage repair.

技术数据 for NCT 02

分子量 312.39
公式 C17H16N2O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 790245-61-3
PubChem ID 2501755
InChI Key IELCYEUTXLYDOV-UHFFFAOYSA-N
Smiles CC1=CN=C(S1)NC(CC2=COC3=C2C=C4CCCC4=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NCT 02

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 31.24 100

制备储备液 for NCT 02

以下数据基于产品分子量 312.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.01 mL 32.01 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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参考文献 for NCT 02

参考文献是支持产品生物活性的出版物。

Dieter et al (2021) Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep. 36 109394 PMID: 34289372

If you know of a relevant reference for NCT 02, please let us know.

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关键词: NCT 02, NCT 02 supplier, NCT02, molecular, glue, proteasomal, degraders, inhibitors, inhibit, inhibition, apoptosis, ubiquitination, CCNK, cyclin, K, CDK12, Molecular, Glues, Transcriptional, CDKs, 7551, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

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