主页 / 药理学 / Enzyme-Linked Receptors / Receptor Tyrosine Kinases (RTKs) / EGFR / EGFR Inhibitors / Neratinib

Neratinib

Cat. No. 7371 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent HER2 receptor tyrosine kinase and EGFR kinase inhibitor
化学名： (2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Neratinib

Neratinib is a potent, irreversible inhibitor of HER-2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50 = 59 nM and 92 nM, respectively). Neratinib reduces receptor autophosphorylation and proliferation of EGFR-dependent cancer cells, blocks cell-cycle progression and inhibits HER-2 signaling pathways. Neratinib suppresses proliferation of gefitinib-resistant non-small cell lung cancer cells expressing mutant EGFR. Also inhibits MST1 (IC50 = 37.7 nM). Orally bioavailable.

技术数据 for Neratinib

分子量 557.05
公式 C30H29ClN6O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 698387-09-6
PubChem ID 9915743
InChI Key JWNPDZNEKVCWMY-VQHVLOKHSA-N
Smiles N(C=1C2=C(C=C(OCC)C(NC(/C=C/CN(C)C)=O)=C2)N=CC1C#N)C3=CC(Cl)=C(OCC4=CC=CC=N4)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Neratinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.79 5

制备储备液 for Neratinib

以下数据基于产品分子量 557.05。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 35.9 mL 179.52 mL 359.03 mL
0.25 mM 7.18 mL 35.9 mL 71.81 mL
0.5 mM 3.59 mL 17.95 mL 35.9 mL
2.5 mM 0.72 mL 3.59 mL 7.18 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Neratinib

参考文献是支持产品生物活性的出版物。

Rabindran et al (2004) Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res. 64 3958 PMID: 15173008

Kwak et al (2005) Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc.Natl.Acad.Sci.U.S.A. 102 7665 PMID: 15897464

Yun et al (2008) The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc.Natl.Acad.Sci.U.S.A. 105 2070 PMID: 18227510

If you know of a relevant reference for Neratinib, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 EGFR Inhibitors

关键词: Neratinib, Neratinib supplier, potent, irreversible, HER2, ERBB2, tyrosine, kinase, inhibitors, inhibitory, inhibition, EGFR, epidermal, growth, factor, receptor, MST1, Other, Kinases, 7371, Tocris Bioscience

篇 Neratinib 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Neratinib 的引用文献。 您是否知道使用了 Tocris Neratinib 的优秀论文？ 请告知我们.

Neratinib 的评论

目前没有该产品的评论。 Be the first to review Neratinib and earn rewards!

Have you used Neratinib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.