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NICE 01

Cat. No. 8088 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
化学名： (R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NICE 01

NICE 01 is a bifunctional molecule consisting of (+)-JQ1 (Cat. No. 4499) and AP 1867 (Cat. No. 6207), with a PEG2-diamine linker. It has a high affinity (Kd = 94 pM) for FKBPF36V tagged proteins. It can induce nuclear localization of cytosolic proteins and target transcriptional regulation. It can be used to calculate the kinetic constant and passive diffusion across the nuclear pore.

技术数据 for NICE 01

分子量 1206.85
公式 C63H76ClN7O13S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2982819-94-1
PubChem ID 169183208
InChI Key USCBOLCYUGPYAF-YUZLDYPQSA-N
Smiles O=C(O[C@H](CCC1=CC=C(C(OC)=C1)OC)C2=CC=CC(OCC(NCCOCCOCCNC(C[C@H]3C4=NN=C(N4C5=C(C(C6=CC=C(C=C6)Cl)=N3)C(C)=C(S5)C)C)=O)=O)=C2)[C@H]7N(CCCC7)C([C@@H](CC)C8=CC(OC)=C(C(OC)=C8)OC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NICE 01

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 60.34 50

制备储备液 for NICE 01

以下数据基于产品分子量 1206.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 1.66 mL 8.29 mL 16.57 mL
2.5 mM 0.33 mL 1.66 mL 3.31 mL
5 mM 0.17 mL 0.83 mL 1.66 mL
25 mM 0.03 mL 0.17 mL 0.33 mL

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参考文献 for NICE 01

参考文献是支持产品生物活性的出版物。

Lu et al (2022) Bioorthogonal chemical epigenetic modifiers enable dose-dependent CRISPR targeted gene activation in mammalian cells. A.C.S.Synth.Biol. 11 1397 PMID: 35302756

Gibson et al (2023) Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. J.Am.Chem.Soc. 145 26028 PMID: 37461636

If you know of a relevant reference for NICE 01, please let us know.

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关键词: NICE 01, NICE 01 supplier, CEM207, FKBPF36V, tagged, proteins, BRD4, FKBP, NICE-01, NICE01, Protein, Dimerizers, 8088, Tocris Bioscience

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