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NK 252

Cat. No. 5293 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Nrf2 activator
化学名： N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NK 252

NK 252 is an Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.

化合物库 for NK 252

NK 252 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NK 252

分子量 285.26
公式 C13H11N5O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1414963-82-8
PubChem ID 71618700
InChI Key FNSCFQXZZNCDAI-UHFFFAOYSA-N
Smiles O=C(NC2=NN=C(C3=CC=CO3)O2)NCC1=CC=CC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NK 252

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 28.53 100
DMSO 28.53 100

制备储备液 for NK 252

以下数据基于产品分子量 285.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.7 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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参考文献 for NK 252

参考文献是支持产品生物活性的出版物。

Shimozono et al (2013) Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol.Pharmacol. 84 62 PMID: 23592516

If you know of a relevant reference for NK 252, please let us know.

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关键词: NK 252, NK 252 supplier, NK252, NRF2, activators, activates, Keap1, Nrf2, 5293, Tocris Bioscience

1 篇 NK 252 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NK 252 的部分引用包括：

Vladimir et al (2021) A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy. Redox Biol 48 102186 PMID: 34801863

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