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Nogo-66 (1-40)

Cat. No. 1984 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration
别名： NEP1-40,Nogo Extracellular Peptide,1-40
纯度： ≥95% (HPLC)
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Nogo-66 (1-40)

Nogo-66 (1-40) is a peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro. Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo.

技术数据 for Nogo-66 (1-40)

分子量 4625.16
公式 C206H324N56O65
序列 RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS

(Modifications: Arg-1 = N-terminal Ac, Ser-40 = C-terminal amide)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 475221-20-6
PubChem ID 16142739
InChI Key OLEKMOOQFWTQGD-SJQNMCRDSA-N
Smiles CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nogo-66 (1-40)

溶解性 Soluble to 1 mg/ml in water

产品说明书 for Nogo-66 (1-40)

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参考文献 for Nogo-66 (1-40)

参考文献是支持产品生物活性的出版物。

GrandPre et al (2002) Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417 547 PMID: 12037567

Liu et al (2002) Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297 1190 PMID: 12089450

Li and Strittmatter (2003) Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J.Neurosci. 23 4219 PMID: 12764110

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关键词: Nogo-66 (1-40), Nogo-66 (1-40) supplier, Competitive, antagonists, Nogo-66, receptor, NGR, neuron, regeneration, NEP140, NEP1-40, Nogo, Extracellular, Peptide,, 1-40, Neuronal, Metabolism, 1984, Tocris Bioscience

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