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说明： Inhibits calcium-sensitive chloride currents
化学名： 5-Nitro-2-(3-phenylpropylamino)benzoic acid
纯度： ≥99% (HPLC)
生物活性 for NPPB
Inhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.
化合物库 for NPPB
NPPB is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for NPPB
| 分子量 | 300.31 |
| 公式 | C16H16N2O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 107254-86-4 |
| PubChem ID | 4549 |
| InChI Key | WBSMIPAMAXNXFS-UHFFFAOYSA-N |
| Smiles | OC(=O)C1=CC(=CC=C1NCCCC1=CC=CC=C1)[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NPPB
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 30.03 | 100 | |
| ethanol | 6.01 | 20 |
制备储备液 for NPPB
以下数据基于产品分子量 300.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.65 mL | 33.3 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
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产品说明书 for NPPB
参考文献 for NPPB
参考文献是支持产品生物活性的出版物。
Keeling et al (1991) Effects of NPPB (5-nitro-1-(3-phenylpropylamino)benzoic acid on chloride transport in intestinal tissues and the T84 cell line. Biochim.Biophys.Acta 115 42 PMID: 1720331
Kirkup et al (1996) Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein. Br.J.Pharmacol. 117 175 PMID: 8825360
Taniguchi et al (2008) 5-nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist Pharmacology 82 245 PMID: 18818509
Wangemann et al (1986) Cl--channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship. Pflugers Arch. 407 S128 PMID: 2434915
If you know of a relevant reference for NPPB, please let us know.
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关键词: NPPB, NPPB supplier, Chloride, channel, blockers, Cl-, Channels, GPR35, Ca2+-Activated, 0593, Tocris Bioscience
10 篇 NPPB 的引用文献
引用文献是使用了 Tocris 产品的出版物。 NPPB 的部分引用包括：
Rastogi et al (2021) Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF PLoS Pathog 17 e1009712 PMID: 34324582
Morethson (2015) Extracellular fluid flow and chloride content modulate H(+) transport by osteoclasts. Cell Death Dis 16 20 PMID: 26271334
Sun et al (2011) Lubiprostone reverses the inhibitory action of mor. on mucosal secretion in human small intestine. Dig Dis Sci 56 330 PMID: 21181441
Fei et al (2009) Stimulation of mucosal secretion by lubipro. (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol 296 G823 PMID: 19179625
Harper and Poole (2013) Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity. J Membr Biol 4 e969 PMID: 24357800
Sagheddu et al (2010) Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells. J Physiol 588 4189 PMID: 20837642
Grant et al (2013) Ionic currents of human trabecular meshwork cells from control and glaucoma subjects. Biol Proced Online 246 167 PMID: 23135060
Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388 PMID: 15616319
Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol 295 C761 PMID: 18596212
Fioretti et al (2005) Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis. Am J Physiol Cell Physiol 289 C89 PMID: 15743891
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NPPB 的评论
平均评分: 5 (Based on 1 Review.)
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A potent chloride channel blocker.
By
Anonymous on 02/19/2018
分析类型： Ex Vivo
种属： Rat
It blocks calcium-activated chloride currents. We used NPPB at 50-100 microM to block chloride channels. It dissolves well in DMSO
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for NPPB
