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NRX 252114

Cat. No. 7990 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Molecular glue Degrader of mutant β-catenin
化学名： 2-[[4-[(2,6-Dichlorophenyl)thio]-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-pyridinyl]carbonyl]-2,3-dihydro-1H-isoindole-4-carbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NRX 252114

NRX-252114 is a potent enhancer of the interaction between S37A mutant β-catenin, and its cognate E3 ligase, SCFβ-TrCP (EC50 = 6.5 nM; Kd = 0.4 nM). NRX-252114 is a molecular glue degrader that binds at the phosphoserine binding site on β-TrCP and induces mutant β-catenin ubiquitination and subsequent degradation.

技术数据 for NRX 252114

分子量 510.31
公式 C22H12Cl2F3N3O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2763260-39-3
PubChem ID 162640509
InChI Key BMQXGPBUQGPLOV-UHFFFAOYSA-N
Smiles N#CC1=CC=CC2=C1CN(C2)C(C3=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)NC3=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NRX 252114

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.03 100
ethanol 5.1 10

制备储备液 for NRX 252114

以下数据基于产品分子量 510.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.8 mL 19.6 mL
5 mM 0.39 mL 1.96 mL 3.92 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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参考文献 for NRX 252114

参考文献是支持产品生物活性的出版物。

Simonetta et al (2019) Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat.Commun. 10 1402 PMID: 30926793

If you know of a relevant reference for NRX 252114, please let us know.

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关键词: NRX 252114, NRX 252114 supplier, NRX252114, e3, ligase, molecular, glue, proximity, inducer, beta, catenin, mutant, S37A, ubiquitination, degradation, degrader, Molecular, Glues, 7990, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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