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Submit ReviewNS 1738 is a selective positive allosteric modulator of α7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α4β2, α3β3 and α1-containing receptors. Displays cognitive-enhancing properties in vivo.
NS 1738 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
分子量 | 365.13 |
公式 | C14H9Cl2F3N2O2 |
储存 | Store at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 501684-93-1 |
PubChem ID | 310378 |
InChI Key | OUDXRNQPVSMGDW-UHFFFAOYSA-N |
Smiles | O=C(NC2=CC(C(F)(F)F)=CC=C2Cl)NC1=C(O)C=CC(Cl)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 36.51 | 100 | |
ethanol | 36.51 | 100 |
以下数据基于产品分子量 365.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.74 mL | 13.69 mL | 27.39 mL |
5 mM | 0.55 mL | 2.74 mL | 5.48 mL |
10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
参考文献是支持产品生物活性的出版物。
Timmermann et al (2007) An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J.Pharmacol.Exp.Ther. 323 294 PMID: 17625074
Freitas et al (2013) The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models. J.Pharmacol.Exp.Ther. 344 264 PMID: 23115222
If you know of a relevant reference for NS 1738, please let us know.
关键词: NS 1738, NS 1738 supplier, Positive, allosteric, modulators, α7, alpha7, a7, nAChR, active, vivo, Nicotinic, Receptors, Acetylcholine, NS1738, PAM, (a7), 2995, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 NS 1738 的部分引用包括:
Bali et al (2019) Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo. Sci Rep 9 9324 PMID: 31249369
Chatzidaki et al (2015) Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons. Neuropharmacology 10 e0125116 PMID: 25906356
Chatzidaki et al (2015) The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors. Int J Oncol 97 75 PMID: 25998276
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