主页 / 细胞生物学 / Cell Metabolism / DNA, RNA and Protein Synthesis / DNA, RNA and Protein Synthesis Inhibitors / NSC 617145

NSC 617145

Cat. No. 5340 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Werner syndrome helicase (WRN) inhibitor
化学名： 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NSC 617145

NSC 617145 is a werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.

技术数据 for NSC 617145

分子量 400.04
公式 C13H10Cl4N2O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 203115-63-3
PubChem ID 357621
InChI Key PCOXPBOKDABARQ-UHFFFAOYSA-N
Smiles CC(CN1C(C(Cl)=C(Cl)C1=O)=O)(C)CN2C(C(Cl)=C(Cl)C2=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NSC 617145

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 8 20

制备储备液 for NSC 617145

以下数据基于产品分子量 400.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 12.5 mL 62.49 mL 124.99 mL
1 mM 2.5 mL 12.5 mL 25 mL
2 mM 1.25 mL 6.25 mL 12.5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for NSC 617145

参考文献是支持产品生物活性的出版物。

Aggarwal et al (2013) Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 73 5497 PMID: 23867477

Aggarwal et al (2013) Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 12 3329 PMID: 24036544

If you know of a relevant reference for NSC 617145, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 DNA, RNA and Protein Synthesis Inhibitors

关键词: NSC 617145, NSC 617145 supplier, NSC617145, Werner, syndrome, helicase, WRN, inhibitors, inhibits, double, strand, breaks, chromosomal, abnormalities, DNA,, RNA, and, Protein, Synthesis, 5340, Tocris Bioscience

1 篇 NSC 617145 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NSC 617145 的部分引用包括：

Robert H et al (2021) WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells. Nat Commun 12 6561 PMID: 34772932

您是否知道使用了 Tocris NSC 617145 的优秀论文？ 请告知我们.

NSC 617145 的评论

目前没有该产品的评论。 Be the first to review NSC 617145 and earn rewards!

Have you used NSC 617145?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells