主页 / 药理学 / Enzymes / Kinases / Cyclin-Dependent Kinases (CDKs) / Cyclin-Dependent Kinase Inhibitors / NSC 693868

NSC 693868

Cat. No. 1937 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1937 has been discontinued.

View all Cyclin-Dependent Kinases (CDKs) products.
说明： Cdk inhibitor; also inhibits GSK-3
化学名： 1H-Pyrazolo[3,4-b]quinoxalin-3-amine
纯度： ≥99% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for NSC 693868

Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.4, 0.6, 4.4 - 5.6 μM for cdk5, cdk1 and cdk2, respectively). Also inhibits GSK-3 (IC50 = 1 uM).

技术数据 for NSC 693868

分子量 185.19
公式 C9H7N5
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 40254-90-8
PubChem ID 438981
InChI Key DWHVZCLBMTZRQM-UHFFFAOYSA-N
Smiles NC1=NN=C2NC3=CC=CC=C3N=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for NSC 693868

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for NSC 693868

参考文献是支持产品生物活性的出版物。

Ortega et al (2002) Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg.Med.Chem.Lett. 10 2177 PMID: 11983514

Monge et al (1995) 3-Amino-2-quinoxalinecarbonitrile. New fused quinoxalines with potential cytotoxic activity. J.Heterocycl.Chem. 31 1135

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Cyclin-Dependent Kinase Inhibitors

关键词: NSC 693868, NSC 693868 supplier, GSK-3, inhibitors, inhibits, cdks, GSK, Glycogen, Synthase, Kinases, 3, Cyclin-Dependent, Protein, Carbohydrate, Metabolism, NSC693868, Cyclin-dependent, Kinase, 1937, Tocris Bioscience

篇 NSC 693868 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 NSC 693868 的引用文献。

NSC 693868 的评论

目前没有该产品的评论。 Be the first to review NSC 693868 and earn rewards!

Have you used NSC 693868?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.