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NTRC 824

Cat. No. 5438 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective non-peptide NTS2 antagonist
化学名： N-[2-[5-[[(4-Methylphenyl)sulfonyl]amino]-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl]acetyl]-L-leucine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for NTRC 824

NTRC 824 is a potent and selective non-peptide neurotensin (NTS) type-2 receptor antagonist (IC50 = 38 nM). Exhibits >150-fold selectivity for NTS2 over NTS1.

化合物库 for NTRC 824

NTRC 824 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for NTRC 824

分子量 553.55
公式 C25H26F3N3O6S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1623002-61-8
PubChem ID 101873359
InChI Key SOOLLEBJNGCDOZ-FQEVSTJZSA-N
Smiles O=C(C(F)(F)F)C2=CN(CC(N[C@@H](CC(C)C)C(O)=O)=O)C1=CC=C(NS(C3=CC=C(C)C=C3)(=O)=O)C=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for NTRC 824

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 55.35 100
ethanol 55.35 100

制备储备液 for NTRC 824

以下数据基于产品分子量 553.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.03 mL 18.07 mL
5 mM 0.36 mL 1.81 mL 3.61 mL
10 mM 0.18 mL 0.9 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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参考文献 for NTRC 824

参考文献是支持产品生物活性的出版物。

Thomas et al (2014) Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-L-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J.Med.Chem. 57 7472 PMID: 25157640

If you know of a relevant reference for NTRC 824, please let us know.

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关键词: NTRC 824, NTRC 824 supplier, NTRC824, neurotensin, receptors, NTS2, non-peptide, potent, selective, antagonists, Neurotensin, Receptors, 5438, Tocris Bioscience

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