NVP DPP 728 dihydrochloride

Name: NVP DPP 728 dihydrochloride
Brand: Tocris Bioscience
SKU: 3506

Cat. No. 3506 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3506 has been discontinued.

View all Dipeptidyl Peptidase IV products.

说明： Potent, orally active dipeptidyl peptidase IV (DPP-IV) inhibitor

化学名： 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride

纯度： ≥97% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for NVP DPP 728 dihydrochloride

Potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor (K_i = 11 nM, IC₅₀ = 14 nM) that displays > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Exhibits antidiabetic activity in vivo; improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, augments insulin secretion and GLUT2 levels, and reduces (preserves) islet size.

技术数据 for NVP DPP 728 dihydrochloride

分子量	371.27
公式	C₁₅H₁₈N₆O.2HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	207556-62-5
PubChem ID	9799555
InChI Key	VNACOBVZDCLAEV-GXKRWWSZSA-N
Smiles	O=C(N2CCC[C@H]2C#N)CNCCNC1=NC=C(C#N)C=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for NVP DPP 728 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for NVP DPP 728 dihydrochloride

参考文献是支持产品生物活性的出版物。

Hughes et al (1999) NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry 38 11597 PMID: 10512614

Reimer et al (2002) Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. Eur.J.Endocrinol. 146 717 PMID: 11980629

Mitani et al (2002) Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early Ins response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. Jpn.J.Pharmacol. 88 451 PMID: 12046989

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1 篇 NVP DPP 728 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 NVP DPP 728 dihydrochloride 的部分引用包括：

Inoue et al (2012) Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Stem Cell Reports 303 G810 PMID: 22821947