主页 / 细胞生物学 / 表观遗传学 / Bromodomains / Bromodomain Inhibitors / OF 1

OF 1

Cat. No. 5289 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5289 has been discontinued.

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说明： Selective BRPF1B and BRPF2 inhibitor
化学名： 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (4)
生物活性 技术数据 说明书 参考文献

生物活性 for OF 1

OF 1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). Exhibits 39-fold selectivity for BRPF1B and BRPF2 over BRD4. Accelerates FRAP recovery at 5 μM in a BRPF2 FRAP assay. Inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the OF 1 probe summary on the SGC website.

化合物库 for OF 1

OF 1 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for OF 1

分子量 440.31
公式 C17H18BrN3O4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 919973-83-4
PubChem ID 35397514
InChI Key YUNQZQREIHWDQT-UHFFFAOYSA-N
Smiles CN1C2=C(C=C(OC)C(NS(C3=C(C)C=C(Br)C=C3)(=O)=O)=C2)N(C)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for OF 1

参考文献是支持产品生物活性的出版物。

Meier et al (2017) Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation. ACS Chem.Biol. 12 2619 PMID: 28849908

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关键词: OF 1, OF 1 supplier, OF1, selective, BRPF1B, BRPF2, bromodomain, inhibitors, inhibits, epigenetics, Bromodomains, 5289, Tocris Bioscience

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