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Submit ReviewOligomycin A
说明： Inhibitor of mitochondrial ATPase
化学名： (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
纯度： ≥98% (HPLC)
生物活性 for Oligomycin A
Oligomycin A is an inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.
技术数据 for Oligomycin A
| 分子量 | 791.06 |
| 公式 | C45H74O11 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 579-13-5 |
| PubChem ID | 5281899 |
| InChI Key | MNULEGDCPYONBU-WMBHJXFZSA-N |
| Smiles | CC[C@](CC[C@@]([H])(O[C@@]2(CC[C@@H](C)[C@@]([H])(C[C@@H](O)C)O2)[C@@H]1C)[C@H](C)[C@]1([H])OC(/C=C/[C@H]([C@@H]([C@@H](C)C([C@@H](C)[C@H](O)[C@H]3C)=O)O)C)=O)([H])/C=C/C=C/C[C@H](C)[C@@H](O)[C@](C)(O)C3=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Oligomycin A
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 7.91 | 10 |
制备储备液 for Oligomycin A
以下数据基于产品分子量 791.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.64 mL | 63.21 mL | 126.41 mL |
| 0.5 mM | 2.53 mL | 12.64 mL | 25.28 mL |
| 1 mM | 1.26 mL | 6.32 mL | 12.64 mL |
| 5 mM | 0.25 mL | 1.26 mL | 2.53 mL |
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产品说明书 for Oligomycin A
参考文献 for Oligomycin A
参考文献是支持产品生物活性的出版物。
Salomon et al (2001) Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem.Biol. 8 71 PMID: 11182320
If you know of a relevant reference for Oligomycin A, please let us know.
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关键词: Oligomycin A, Oligomycin A supplier, OligomycinA, inhibitors, mitochondrial, ATPase, inhibits, oxidative, phosphorylation, antibiotics, Other, ATPases, Antibiotics, 4110, Tocris Bioscience
10 篇 Oligomycin A 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Oligomycin A 的部分引用包括：
Roland et al (2020) Metabolic Profiling of Single Cancer Cells Using Mitochondrial ATP Probes. STAR Protoc 1 100048 PMID: 33111094
Yonghyun et al (2020) Cellular uptake of protic ruthenium complexes is influenced by pH dependent passive diffusion and energy dependent efflux. J Inorg Biochem 203 110922 PMID: 31775072
Shin et al (2017) Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice. Cell Metab 26 764 PMID: 28988822
P Darrell et al (2021) Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia. Elife 10 PMID: 34132194
Kurt I et al (2021) Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms. Cell Rep 34 108750 PMID: 33596424
Hongbo et al (2021) Investigating the Dynamic Changes in iNKT Cell Metabolic Profiles During Development. Methods Mol Biol 2388 181-192 PMID: 34524673
Bernd et al (2021) The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments. Int J Mol Sci 22 PMID: 33923223
Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329
Depaoli et al (2018) Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells. Cell Rep 25 501 PMID: 30304688
Roland C et al (2013) The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing. Mol Inform 32 47-63 PMID: 27481023
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Oligomycin A 的评论
平均评分: 4 (Based on 1 Review.)
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Oligomycin A was used in oxidative phosphorylation studies.
By
Jade Smith on 02/05/2019
分析类型： In Vivo
种属： Mouse
Oligomycin A was used in oxidative phosphorylation studies. Its action on protein channel blocking was being studied. Performed well and gives repeatable results.
