主页 / 药理学 / Enzymes / Kinases / Cyclin-Dependent Kinases (CDKs) / Cyclin-Dependent Kinase Inhibitors / Olomoucine

Olomoucine

Cat. No. 1284 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1284 has been discontinued.

View all Cyclin-Dependent Kinases (CDKs) products.
说明： Cdk inhibitor
化学名： 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Olomoucine

ATP-competitive cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.6 and 0.94 - 8 μM for cdk7 and cdk2 respectively, and >1 μM for cdk1 and cdk9. Induces cell cycle arrest at G1 in human fibroblasts.

技术数据 for Olomoucine

分子量 298.35
公式 C15H18N6O
储存 Desiccate at -20°C
CAS Number 101622-51-9
PubChem ID 4592
InChI Key GTVPOLSIJWJJNY-UHFFFAOYSA-N
Smiles CN1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Olomoucine

参考文献是支持产品生物活性的出版物。

Abraham et al (1995) Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biol.Cell 83 105 PMID: 7549905

Alessi et al (1998) The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp.Cell.Res. 245 8 PMID: 9828096

Vesely et al (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur.J.Biochem. 224 771 PMID: 7925396

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Cyclin-Dependent Kinase Inhibitors

关键词: Olomoucine, Olomoucine supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdks, Kinase, 1284, Tocris Bioscience

1 篇 Olomoucine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Olomoucine 的部分引用包括：

Cannon et al (2009) Association of luteinizing hormone receptor gene expression with cell cycle progression in granulosa cells. Am J Physiol Endocrinol Metab 296 E1392 PMID: 19293332

Olomoucine 的评论

目前没有该产品的评论。 Be the first to review Olomoucine and earn rewards!

Have you used Olomoucine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.