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Omeprazole

Cat. No. 2583 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2583 has been discontinued.

View all H<sup>+</sup>,K<sup>+</sup>-ATPase products.
说明： H+,K+-ATPase inhibitor
化学名： 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Omeprazole

Omeprazole is a H+,K+-ATPase inhibitor (IC50 = 5.8 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.16 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro. Also inhibits CYP2C19, CYP2C9 and CYP3A (Ki values are 3.1, 40.1 and 84.4 μM respectively) and blocks swelling-dependent chloride channels (ICIswell). Enhances anti-SARS-CoV-2 acitvity of Remdesivir and Aprotinin (Cat. No. 4139).

技术数据 for Omeprazole

分子量 345.42
公式 C17H19N3O3S
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 73590-58-6
PubChem ID 4594
InChI Key SUBDBMMJDZJVOS-UHFFFAOYSA-N
Smiles COC1=CC=C2N=C(NC2=C1)S(=O)CC1=C(C)C(OC)=C(C)C=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Omeprazole

参考文献是支持产品生物活性的出版物。

Satoh et al (1989) Antisecretory and anitulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806 PMID: 2537418

Richardson et al (1998) Proton pump inhibitors. Drugs 56 307 PMID: 9777309

Schmarda et al (2000) The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598 PMID: 10711360

Bojkova et al (2020) SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles. BioRxiv - Paper not yet peer reviewed.

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关键词: Omeprazole, Omeprazole supplier, H+K+-ATPase, inhibitors, inhibits, Hydrogen, Potassium-ATPase, Ion, Transporters, Pumps, ATPases, cytochrome, p450, CYP2C19, CYP2C9, CYP3A, SARS-CoV-2, COVID-19, severe, acute, respiratory, syndrome, H+,K+-ATPase, Cytochrome, P450, Coronavirus, 2583, Tocris Bioscience

篇 Omeprazole 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Omeprazole 的引用文献。

Omeprazole 的评论

平均评分: 5 (Based on 1 Review.)

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Enzimes in the Lab.
By Anonymous on 01/04/2018
分析类型： In Vitro
种属： Rat
细胞系/组织： blood

We use it in the pharmacology lab for the assigment experiments

We prepare the solutions the same day of use