ONO 2506

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说明: Inhibits S-100β synthesis; neuroprotective
别名: Arundic acid
化学名: (2R)-2-Propyloctanoic acid
说明书
引用文献 (1)
评论

生物活性 for ONO 2506

ONO 2506 inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.

技术数据 for ONO 2506

分子量 186.29
公式 C11H22O2
储存 Store at +4°C
CAS Number 185517-21-9
PubChem ID 208925
InChI Key YCYMCMYLORLIJX-SNVBAGLBSA-N
Smiles CCC[C@H](CCCCCC)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ONO 2506

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.63 100
ethanol 18.63 100

制备储备液 for ONO 2506

以下数据基于产品分子量 186.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 5.37 mL 26.84 mL 53.68 mL
5 mM 1.07 mL 5.37 mL 10.74 mL
10 mM 0.54 mL 2.68 mL 5.37 mL
50 mM 0.11 mL 0.54 mL 1.07 mL

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产品说明书 for ONO 2506

分析证书/产品说明书
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参考文献 for ONO 2506

参考文献是支持产品生物活性的出版物。

Kato et al (2004) Arundic acid, an astrocyte-modulating agent, protects DArgic neurons against MPTP neurotoxicity in mice. Brain Res. 1030 66 PMID: 15567338

Tateishi et al (2002) Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early J.Cereb.Blood Flow Metab. 22 723 PMID: 12045671

Mori et al (2006) Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. J.Pharmacol.Exp.Ther. 318 571 PMID: 16709678


If you know of a relevant reference for ONO 2506, please let us know.

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关键词: ONO 2506, ONO 2506 supplier, ONO2506, S100B, bbb, blood, brain, barrier, stroke, neuroprotective, Alzheimer's, parkinson's, disease, astrocytes, astrocytic, arundic, acid, parkinsons, alzheimers, Arundic, Neuronal, Metabolism, 4530, Tocris Bioscience

1 篇 ONO 2506 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ONO 2506 的部分引用包括:

Hao et al (2017) Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development. Front Cell Neurosci 11 42 PMID: 28280459


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