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ONO 6818

Cat. No. 5651 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active
化学名： 5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ONO 6818

ONO 6818 is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM). Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits HNE-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.

化合物库 for ONO 6818

ONO 6818 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ONO 6818

分子量 452.51
公式 C23H28N6O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 208848-19-5
PubChem ID 216294
InChI Key YSIHYROEMJSOAS-UHFFFAOYSA-N
Smiles O=C(NC(C(C)C)C(C1=NN=C(C(C)(C)C)O1)=O)CN(C(C2=CC=CC=C2)=NC=C3N)C3=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ONO 6818

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.25 100

制备储备液 for ONO 6818

以下数据基于产品分子量 452.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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参考文献 for ONO 6818

参考文献是支持产品生物活性的出版物。

Hirota et al (2004) Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters. J.Vet.Med.Sci. 66 1223 PMID: 15528853

Aoshiba et al (2001) Serine proteases increase oxidative stress in lung cells. Am.J.Physiol.Lung Cell Mol.Physiol. 281 556 PMID: 11504681

Stevens et al (2011) AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J.Pharmacol.Exp.Ther. 339 313 PMID: 21791628

If you know of a relevant reference for ONO 6818, please let us know.

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关键词: ONO 6818, ONO 6818 supplier, ONO6818, High, affinity, selective, human, neutraphil, elastases, 1, HNE1, inhibitors, inhibits, COPD, chronic, obstructive, pulmonary, disease, colitis, orally, active, Elastase, 5651, Tocris Bioscience

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