Ortho AP 1867

Cat. No. 7787 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective binding ligand for FKBP12^F36V; precursor for dTAG compounds

化学名： 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid

纯度： ≥98% (HPLC)

文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ortho AP 1867

Ortho AP 1867 is a selective binding ligand for the single point mutant of FKBP12^F36V. Functionalized with a carboxylic acid group in the ortho-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with compound binding ability. Ortho AP 1867 is a precursor for the dTAG compounds.

技术数据 for Ortho AP 1867

分子量	693.79
公式	C₃₈H₄₇NO₁₁
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2230613-03-1
PubChem ID	133080821
InChI Key	UYXSZUBFOQLRNQ-BTIIJPOSSA-N
Smiles	CC[C@@H](C1=CC(OC)=C(C(OC)=C1)OC)C(N2CCCC[C@H]2C(O[C@@H](C3=CC=CC=C3OCC(O)=O)CCC4=CC(OC)=C(C=C4)OC)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ortho AP 1867

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	69.38	100

制备储备液 for Ortho AP 1867

以下数据基于产品分子量 693.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.44 mL	7.21 mL	14.41 mL
5 mM	0.29 mL	1.44 mL	2.88 mL
10 mM	0.14 mL	0.72 mL	1.44 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

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产品说明书 for Ortho AP 1867

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ortho AP 1867

参考文献是支持产品生物活性的出版物。

Nabet et al (2018) The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 14 431 PMID: 29581585

If you know of a relevant reference for Ortho AP 1867, please let us know.

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关键词: Ortho AP 1867, Ortho AP 1867 supplier, ortho, AP1867, FKBP12, F36V, dTAG, selective, binding, ligand, carboxylic, acid, functionalized, TAG, Degradation, Platform, 7787, Tocris Bioscience

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TPD and Induced Proximity Research Product GuideUpdated

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia

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The dTAG platform offers a generalizable strategy to degrade, in principle, any intracellular protein of interest (POI) and is a useful strategy for exploration and validation of targets. This poster presents a workflow solution for target validation, from custom TAG knock-in cell-lines for your POI, different dTAG Degraders to knockdown you POI, to automated assays for protein degradation using Simple Western^TM instruments. Data are also presented on the use of an antibody that recognizes the TAG domain (FKBP12^F36V) for detection of degradation. Presented at TPD Europe, March 2022, London, UK.