Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewOzanimod
说明： Potent and selective S1P1 and S1P5 agonist
化学名： 5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
纯度： ≥98% (HPLC)
生物活性 for Ozanimod
Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist (EC50 values are 0.41 and 11 nM, respectively, in a [35S]-GTPγS assay). Ozanimod exhibits 27-fold selectivity over S1P5, and >10,000-fold selectivity over S1P2-4. In vitro, Ozanimod induces sustained S1P1 receptor internalization and degradation in S1P1 receptor-HEK293T cells. In vivo, Ozanimod reduces inflammation and disease parameters in rat models of autoimmune disease. Ozanimod reduces chronic inflammation and alleviates kidney pathology in a murine model of systemic lupus erythematosus. Ozanimod is orally bioavailable.
化合物库 for Ozanimod
Ozanimod is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Ozanimod
| 分子量 | 404.46 |
| 公式 | C23H24N4O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1306760-87-1 |
| PubChem ID | 52938427 |
| InChI Key | XRVDGNKRPOAQTN-FQEVSTJZSA-N |
| Smiles | N(CCO)[C@@H]1C=2C(=C(C=CC2)C=3N=C(ON3)C4=CC(C#N)=C(OC(C)C)C=C4)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ozanimod
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.45 | 100 |
制备储备液 for Ozanimod
以下数据基于产品分子量 404.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.36 mL | 24.72 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Ozanimod
参考文献 for Ozanimod
参考文献是支持产品生物活性的出版物。
Scott et al (2016) Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune diseasemodifying activity. Br.J.Pharmacol. 173 1778 PMID: 26990079
Selkirk et al (2021) Deconstructing the pharmacological contribution of sphingosine-1 phosphate receptors to mouse models of multiple sclerosis using the species selectivity of ozanimod, a dual modulator of human sphingosine 1-phosphate receptor subtypes 1 and 5. J.Pharmacol.Exp.Ther. 379 379 PMID: 34535564
R Taylor Meadows et al (2018) Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus. PLoS One 13 e0193236 PMID: 29608575
If you know of a relevant reference for Ozanimod, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: Ozanimod, Ozanimod supplier, sphingosine-1-phosphate, receptors, S1P1, S1P5, potent, selective, agonists, agonism, orally, bioavailable, SLE, systemic, lupus, erythematosus, Sphingosine-1-phosphate, Receptors, 7663, Tocris Bioscience
篇 Ozanimod 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 Ozanimod 的引用文献。 您是否知道使用了 Tocris Ozanimod 的优秀论文？ 请告知我们.
Ozanimod 的评论
目前没有该产品的评论。 Be the first to review Ozanimod and earn rewards!
Have you used Ozanimod?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image