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PA 8

Cat. No. 6657 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： PAC1 receptor antagonist
化学名： 2-Amino-5,8-dihydro-5-[3-methoxy-4-(2-propen-1-yloxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PA 8

PA 8 is a PAC1 receptor antagonist. Inhibits PACAP-induced CREB phosphorylation in PAC1, but not VPAC1 or VPAC2, expressing cells. Also inhibits PACAP-induced increases in cAMP levels in vitro (IC50 = 2 nM) and PACAP-induced aversive responses and mechanical allodynia following intrathecal injection in vivo.

化合物库 for PA 8

PA 8 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PA 8

分子量 342.35
公式 C17H18N4O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 878437-15-1
PubChem ID 6485327
InChI Key DCSWTWUTSKSXOV-UHFFFAOYSA-N
Smiles COC1=C(C=CC(C2CC(NC3=C2C(N=C(N3)N)=O)=O)=C1)OCC=C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PA 8

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.12 50

制备储备液 for PA 8

以下数据基于产品分子量 342.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.84 mL 29.21 mL 58.42 mL
2.5 mM 1.17 mL 5.84 mL 11.68 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
25 mM 0.12 mL 0.58 mL 1.17 mL

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参考文献 for PA 8

参考文献是支持产品生物活性的出版物。

Takasaki et al (2018) In silico screening identified novel small-molecule antagonists of PAC1 receptor. J.Pharmacol.Exp.Ther. 365 1 PMID: 29363578

If you know of a relevant reference for PA 8, please let us know.

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关键词: PA 8, PA 8 supplier, PA8, Pituitary, adenylate, cyclase-activating, polypeptide, PACAP, receptors, antagonists, antagonism, PAC1, analgesics, analgesia, Receptors, 6657, Tocris Bioscience

1 篇 PA 8 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PA 8 的部分引用包括：

Varodayan et al (2020) PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress. Neuropharmacology 168 PMID: 31476352

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