PACAP Receptors
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.
PACAP Receptor Agonists |
|
|---|---|
| Cat. No. | 产品名称/活性 |
| 1183 | PACAP 1-27 |
| Potent stimulator of adenylyl cyclase | |
| 1186 | PACAP 1-38 |
| Potent stimulator of adenylyl cyclase | |
PACAP Receptor Antagonists |
|
| Cat. No. | 产品名称/活性 |
| 6657 | PA 8 |
| PAC1 receptor antagonist | |
| 3236 | PACAP 6-38 |
| Potent PAC1 receptor antagonist | |
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2.
PAC1 receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb, thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock, emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human PAC1 receptor gene has been localized to chromosome 7p14.