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Submit ReviewParthenolide
说明： 5-HT release inhibitor
化学名： [1aR-(1aR*,4E,7aS*,10aS*,-10bR*)]-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
纯度： ≥98% (HPLC)
生物活性 for Parthenolide
The active principle of feverfew (Chrysanthemum parthenium). Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits activation of NF-κB, and generation of leukotriene B4 and thromboxane B2.
化合物库 for Parthenolide
Parthenolide is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Parthenolide
| 分子量 | 248.32 |
| 公式 | C15H20O3 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 20554-84-1 |
| PubChem ID | 6473881 |
| InChI Key | KTEXNACQROZXEV-SLXBATTESA-N |
| Smiles | C/C1=C\CC[C@]2(C)[C@@H](O2)[C@@H](OC([C@]3=C)=O)[C@H]3CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Parthenolide
参考文献 for Parthenolide
参考文献是支持产品生物活性的出版物。
Groenewegen and Heptinstall (1990) A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro. J.Pharm.Pharmacol. 42 553 PMID: 1981582
Heptinstall et al (1986) Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit. J.Pharm.Pharmacol. 38 709 PMID: 2877077
Sumner et al (1992) Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem.Pharmacol. 43 2313 PMID: 1319159
Hehner et al (1998) Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J.Biol.Chem. 273 1288 PMID: 9430659
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关键词: Parthenolide, Parthenolide supplier, 5-HT, release, inhibitors, inhibits, Serotonin, 5-Hydroxytryptamine, Receptors, 5-HT3, feverfew, 5-HT-Related, NF-kB/IkB, 0610, Tocris Bioscience
2 篇 Parthenolide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Parthenolide 的部分引用包括：
Lee et al (2016) Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Anesth Analg 7 11322 PMID: 27089465
Schwarz et al (2011) Parthenolide Blocks Cocaine's Effect on Spontaneous Firing Activity of DArgic Neurons in the Ventral Tegmental Area. Curr Neuropharmacol 9 17 PMID: 21886554
Parthenolide 的评论
平均评分: 5 (Based on 1 Review.)
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Parthenolide as a behavioral cocaine antagonist.
By
One Pagan on 01/10/2018
分析类型： In Vivo
种属： Other
Behavioral evaluation of antagonistic effects of parthenolide on cocaine effects in planarians
I have used Tocris’ Parthenolide (Cat. No. 0610) for a few years in my research program searching for behavioral antagonists of cocaine. This research has resulted in 5 peer-reviewed papers and the discovery story is included in a chapter of my book The First Brain: The Neuroscience of Planarians and in a review paper (shown in the figure). There are at least 4 more papers in preparation and the project is still going strong. In the initial phases of my project, I evaluated several suppliers of parthenolide and Tocris’ offering consistently came ahead in terms of customer service and compound purity, and I do not intend to change suppliers. I recommend this product and the company without reservation.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.