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PCNA I1

Cat. No. 5419 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5419 has been discontinued.

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说明： PCNA inhibitor
化学名： N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for PCNA I1

PCNA I1 is a proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 μM), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.

技术数据 for PCNA I1

分子量 310.37
公式 C17H14N2O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 444930-42-1
PubChem ID 5410824
InChI Key WNYIQPCMVYAJLQ-JLHYYAGUSA-N
Smiles O=C(C1=C(C)C=CS1)N/N=C/C2=C(O)C3=CC=CC=C3C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PCNA I1

参考文献是支持产品生物活性的出版物。

Tan et al (2012) Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Mol.Pharmacol. 81 811 PMID: 22399488

Dillehay et al (2014) Antitumor effects of a novel small molecule targeting PCNA chromatin association in prostate cancer. Mol.Cancer Ther. 13 2817 PMID: 25253786

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关键词: PCNA I1, PCNA I1 supplier, PCNA11, Proliferating, cell, nuclear, antigen, PCNA, inhibits, inhibitors, anticancer, cycle, arrest, DNA,, RNA, and, Protein, Synthesis, 5419, Tocris Bioscience

篇 PCNA I1 的引用文献

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PCNA I1 的评论

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PCNAI1 quickly kills melanoma cells in vitro.
By Anonymous on 02/14/2019
分析类型： In Vitro
种属： Human

PCNA I1 was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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