PD 150606

Cat. No. 1269 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cell permeable calpain inhibitor

化学名： (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid

纯度： ≥95% (HPLC)

引用文献 (6)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PD 150606

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (K_i values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.

技术数据 for PD 150606

分子量	306.12
公式	C₉H₇IO₂S
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	179528-45-1
PubChem ID	9839500
InChI Key	DJCVSFWGKYHMKH-YVMONPNESA-N
Smiles	IC1=CC=C(/C=C(C(O)=O)\S)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PD 150606

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	30.61	100
	ethanol	15.31	50

制备储备液 for PD 150606

以下数据基于产品分子量 306.12。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.27 mL	16.33 mL	32.67 mL
5 mM	0.65 mL	3.27 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.27 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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产品说明书 for PD 150606

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PD 150606

参考文献是支持产品生物活性的出版物。

Squier et al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 178 311 PMID: 9989777

Wang et al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 93 6687 PMID: 8692879

Waters et al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 283 1177 PMID: 9399991

If you know of a relevant reference for PD 150606, please let us know.

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关键词: PD 150606, PD 150606 supplier, PD150606, calpain, inhibitors, inhibits, selective, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Calpains, 1269, Tocris Bioscience

6 篇 PD 150606 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PD 150606 的部分引用包括：

Chang et al (2017) Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. Elife 6 PMID: 29271742

Pradhan et al (2017) The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability. J Mol Biol 429 192 PMID: 27986570

Getz et al (2016) Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons. Sci Rep 6 31779 PMID: 27538741

Chamma et al (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. J Neurosci 33 15488 PMID: 24068817

Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. PLoS One 6 9173 PMID: 25823819

Alvarez-Arce (2017) Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization. Int J Cell Biol 2017 1908310 PMID: 29250115

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Pathways for PD 150606

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.