PD 166793

Cat. No. 2520 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Broad spectrum MMP inhibitor

化学名： N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PD 166793

PD 166793 is a broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC₅₀ values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

化合物库 for PD 166793

PD 166793 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PD 166793

分子量	412.3
公式	C₁₇H₁₈BrNO₄S
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	199850-67-4
PubChem ID	9887870
InChI Key	GJOCABIDMCKCEG-INIZCTEOSA-N
Smiles	BrC1=CC=C(C2=CC=C(S(N[C@@H]([C@H](C)C)C(O)=O)(=O)=O)C=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PD 166793

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	41.23	100
	ethanol	41.23	100

制备储备液 for PD 166793

以下数据基于产品分子量 412.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.13 mL	24.25 mL
5 mM	0.49 mL	2.43 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for PD 166793

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PD 166793

参考文献是支持产品生物活性的出版物。

O'Brien et al (2000) Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available Biphenylsulfonamide matrix metalloproteinase inhibitors. J.Med.Chem. 43 156 PMID: 10649971

Peterson et al (2001) Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Circulation 103 2303 PMID: 11342481

Chancey et al (2002) Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload. Circulation 105 1983 PMID: 11997287

If you know of a relevant reference for PD 166793, please let us know.

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关键词: PD 166793, PD 166793 supplier, Broad, spectrum, MMP, inhibitors, inhibits, Matrixins, Matrix, Metalloproteinase, Metalloprotease, Proteinases, Proteases, PD166793, 2520, Tocris Bioscience

1 篇 PD 166793 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PD 166793 的部分引用包括：

Bencsik et al (2018) Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection. Front Pharmacol 9 296 PMID: 29674965

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