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Pepstatin A

Cat. No. 1190 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective and high affinity cathepsin D inhibitor
纯度： ≥95% (HPLC)
说明书
引用文献 (3)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Pepstatin A

Pepstatin A is an irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).

技术数据 for Pepstatin A

分子量 685.91
公式 C34H63N5O9
序列 VVXAX

(Modifications: Val-1 = N-terminal iso-Valeryl, X-3 = X-5 = Sta)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 26305-03-3
PubChem ID 5478883
InChI Key FAXGPCHRFPCXOO-LXTPJMTPSA-N
Smiles O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Pepstatin A

溶解性 Soluble to 1 mg/ml in ethanol with gentle warming

产品说明书 for Pepstatin A

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Pepstatin A

参考文献是支持产品生物活性的出版物。

Marciniszyn et al (1976) Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 251 7088 PMID: 993206

Sato et al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677 PMID: 17942897

Gacko et al (2007) Cathepsin D inhibitors. Folia Histochem.Cytobiol. 45 291 PMID: 18165168

Mizuochi et al (1997) Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain. Immunol.Lett. 43 189 PMID: 7721331

If you know of a relevant reference for Pepstatin A, please let us know.

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关键词: Pepstatin A, Pepstatin A supplier, Aspartic, protease, inhibitors, inhibits, Proteases, Proteinases, PepstatinA, cathepsin, D, selective, high, affinity, Autophagy, Cathepsin, 1190, Tocris Bioscience

3 篇 Pepstatin A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Pepstatin A 的部分引用包括：

Berg et al (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Rep 27 2837 PMID: 31167131

Tsai et al (2013) WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. J Neurosci 4 e792 PMID: 24008736

Guerroue et al (2017) Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell 68 786 PMID: 29149599

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Pepstatin A 的评论

平均评分: 5 (Based on 1 Review.)

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good performance.
By Estela Correa on 07/27/2022
分析类型： Ex Vivo
种属： Mouse

1:1000. Performed ideally

Leave in a container to prevent exposure to moisture.