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PF 06260933 dihydrochloride

Cat. No. 5752 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK
化学名： 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PF 06260933 dihydrochloride

PF 06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PF 06260933 dihydrochloride

PF 06260933 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 06260933 dihydrochloride

分子量 369.68
公式 C16H13ClN4.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1883548-86-4
PubChem ID 118701007
InChI Key VRQXEOPUAQLBQI-UHFFFAOYSA-N
Smiles NC1=NC=C(C3=CN=C(N)C=C3)C=C1C2=CC=C(Cl)C=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 06260933 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 36.97 100
DMSO 7.39 20

制备储备液 for PF 06260933 dihydrochloride

以下数据基于产品分子量 369.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.53 mL 27.05 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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产品说明书 for PF 06260933 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for PF 06260933 dihydrochloride

参考文献是支持产品生物活性的出版物。

Ammirati et al (2015) Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment. ACS Med.Chem.Lett. 6 1128 PMID: 26617966

If you know of a relevant reference for PF 06260933 dihydrochloride, please let us know.

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关键词: PF 06260933 dihydrochloride, PF 06260933 dihydrochloride supplier, PF06260933, dihydrochloride, MAP4K4, HGK, inhibitors, inhibits, antidiabetic, diabetes, MINK, TNIK, mitogen-activated, kinases, hepatocyte, germinal, pogenitor, kinase-like, center, kinase, Other, MAPK, Kinases, 5752, Tocris Bioscience

2 篇 PF 06260933 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PF 06260933 dihydrochloride 的部分引用包括：

Sebastian et al (2019) Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents. Cell Chem Biol 26 1703-1715.e37 PMID: 31676236

Gao et al (2017) MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance. Mol Oncol 11 628 PMID: 28306189

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.