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Submit ReviewPF 3084014 hydrobromide
说明： Potent γ-secretase inhibitor
化学名： (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide
纯度： ≥98% (HPLC)
生物活性 for PF 3084014 hydrobromide
PF 3084014 hydrobromide is a potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 3084014 hydrobromide
| 分子量 | 651.47 |
| 公式 | C27H41F2N5O.HBr |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1962925-29-6 |
| PubChem ID | 121513889 |
| InChI Key | LXEYYZYDWLAIPW-KBVFCZPLSA-N |
| Smiles | O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PF 3084014 hydrobromide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 6.51 | 10 温和加热 | |
| DMSO | 65.15 | 100 |
制备储备液 for PF 3084014 hydrobromide
以下数据基于产品分子量 651.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.53 mL | 7.67 mL | 15.35 mL |
| 5 mM | 0.31 mL | 1.53 mL | 3.07 mL |
| 10 mM | 0.15 mL | 0.77 mL | 1.53 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
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产品说明书 for PF 3084014 hydrobromide
参考文献 for PF 3084014 hydrobromide
参考文献是支持产品生物活性的出版物。
Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID: 20363853
If you know of a relevant reference for PF 3084014 hydrobromide, please let us know.
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关键词: PF 3084014 hydrobromide, PF 3084014 hydrobromide supplier, PF3084014, hydrobromide, gamma, secretase, inhibitors, inhibits, γ, Abeta, amyloid, β, Gamma-Secretase, Amyloid, Beta, Peptides, 5751, Tocris Bioscience
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