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Submit ReviewPF 3716556
Discontinued Product
4191 has been discontinued.
View all H<sup>+</sup>,K<sup>+</sup>-ATPase products.
说明： Selective H+,K+-ATPase inhibitor
化学名： 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide
纯度： ≥98% (HPLC)
生物活性 for PF 3716556
PF 3716556 is a H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays); more potent in acidic conditions. Highly selective for H+,K+-ATPase in vitro; displays no activity at Na+,K+-ATPase. Also displays selectivity for H+,K+-ATPase over a range of 50 receptors and ion channels (IC50 > 10 μM). Inhibits gastric acid secretion in rat and dog models.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for PF 3716556
| 分子量 | 394.47 |
| 公式 | C22H26N4O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 928774-43-0 |
| PubChem ID | 25134521 |
| InChI Key | YBHKBMJREUZHOV-QGZVFWFLSA-N |
| Smiles | OCCN(C)C(C2=CN1C(C(N[C@H]4C3=C(C)C=CC=C3OCC4)=C2)=NC(C)=C1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PF 3716556
参考文献 for PF 3716556
参考文献是支持产品生物活性的出版物。
Mori et al (2009) N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesop J.Pharmacol.Exp.Ther. 328 671 PMID: 18981288
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关键词: PF 3716556, PF 3716556 supplier, selective, inhibitors, inhibits, H+K+-ATPase, hydrogen, potassium-ATPase, ion, transporters, pumps, ATPases, PF3716556, pfizer, H+,K+-ATPase, 4191, Tocris Bioscience
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