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PFM 01

Cat. No. 6222 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6222 has been discontinued.

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说明： MRE11 endonuclease inhibitor
化学名： (5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for PFM 01

PFM 01 is a MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.

技术数据 for PFM 01

分子量 293.4
公式 C14H15NO2S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1558598-41-6
PubChem ID 2145809
InChI Key GPURHDUTZUYAFI-GHXNOFRVSA-N
Smiles CC(CN1C(S/C(C1=O)=C\C2=CC=C(C=C2)O)=S)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PFM 01

参考文献是支持产品生物活性的出版物。

Shibata et al (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol.Cell 53 7 PMID: 24316220

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关键词: PFM 01, PFM 01 supplier, PFM01, MRE11, meiotic, recombination, 11, homolog, A, endonuclease, inhibitors, inhibits, non-homologous, end-joining, NHEJ, HR, DNA,, RNA, and, Protein, Synthesis, 6222, Tocris Bioscience

2 篇 PFM 01 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PFM 01 的部分引用包括：

George-Lucian et al (2022) The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1. Nat Commun 13 5063 PMID: 36030235

Benedikt M et al (2021) p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation. Cell Rep 35 109153 PMID: 34038735

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