Phosphoramidon disodium salt

Cat. No. 6333 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Neutral endopeptidase and endothelin converting enzyme inhibitor

化学名： N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt

纯度： ≥95% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Phosphoramidon disodium salt

Phosphoramidon disodium salt is a neutral endopeptidase (neprilysin) inhibitor. Blocks degradation of amyloid β peptides and increases Aβ levels in rodents. Also blocks endothelin converting enzyme (ECE).

技术数据 for Phosphoramidon disodium salt

分子量	587.47
公式	C₂₃H₃₂N₃Na₂O₁₀P
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	164204-38-0
PubChem ID	16219931
InChI Key	OQKHVXFOYFBMDJ-ODIUWQMJSA-L
Smiles	CC(C[C@@H](C(N[C@H](C(O[Na])=O)CC1=CNC2=CC=CC=C12)=O)NP(O[C@@H]3O[C@H]([C@@H]([C@H]([C@H]3O)O)O)C)(O[Na])=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Phosphoramidon disodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	58.75	100

制备储备液 for Phosphoramidon disodium salt

以下数据基于产品分子量 587.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.7 mL	8.51 mL	17.02 mL
5 mM	0.34 mL	1.7 mL	3.4 mL
10 mM	0.17 mL	0.85 mL	1.7 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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产品说明书 for Phosphoramidon disodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Phosphoramidon disodium salt

参考文献是支持产品生物活性的出版物。

Marr and Hafez (2014) Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Front.Aging Neurosci. 6 187 PMID: 25165447

Shirotani et al (2001) Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J.Biol.Chem. 276 21895 PMID: 11278416

Warner et al (1992) Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA. Br.J.Pharmacol. 106 948 PMID: 1393292

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关键词: Phosphoramidon disodium salt, Phosphoramidon disodium salt supplier, neprilysin, neutral, metallo, endopeptidase, endothelin, converting, enzyme, ECE, inhibitors, inhibits, 119942-99-3, NEP, CD10, MME, Other, Proteases, 6333, Tocris Bioscience

1 篇 Phosphoramidon disodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Phosphoramidon disodium salt 的部分引用包括：

Bruce L et al (2021) Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration. Mol Neurodegener 16 51 PMID: 34344440

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