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Submit ReviewPiceatannol
说明： Inhibits TNF-induced NF-κB activation
化学名： 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol
纯度： ≥98% (HPLC)
生物活性 for Piceatannol
Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol (Cat. No. 1418) by cytochrome P450 1B1.
技术数据 for Piceatannol
| 分子量 | 244.25 |
| 公式 | C14H12O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 10083-24-6 |
| PubChem ID | 667639 |
| InChI Key | CDRPUGZCRXZLFL-OWOJBTEDSA-N |
| Smiles | OC1=CC(\C=C\C2=CC(O)=C(O)C=C2)=CC(O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Piceatannol
参考文献 for Piceatannol
参考文献是支持产品生物活性的出版物。
Ashikawa et al (2002) Piceatannol inhibits TNF-induced NF-kB activation and NF-kB-mediated gene expression through suppression of IkBa kinase and p65 phosphorylation. J.Immunol. 169 6490 PMID: 12444159
Geahlen and McLaughlin (1989) Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochem.Biophys.Res.Commun. 165 241 PMID: 2590224
Oliver et al (1994) Inhibition of mast cell FceR1-mediated signalling and effector function by the syk-selective inhibitor, piceatannol. J.Biol.Chem. 269 29697 PMID: 7961959
Potter et al (2002) The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br.J.Cancer 86 774 PMID: 11875742
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关键词: Piceatannol, Piceatannol supplier, Syk, p56lck, kinase, inhibitors, inhibits, TNF-induced, NF-κB, NF-kappaB, NF-kB, activation, Kinases, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, Src, Kinase, NF-kB/IkB, 1554, Tocris Bioscience
8 篇 Piceatannol 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Piceatannol 的部分引用包括：
Farrand et al (2013) Piceatannol enhances cisp. sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. J Biol Chem 288 23740 PMID: 23833193
Shin et al (2015) TH2 cells and their cytokines regulate formation and function of lymphatic vessels. Nat Commun 6 6196 PMID: 25648335
Bakema et al (2015) Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs. J Immunol 194 1856 PMID: 25582855
Meyer et al (2012) A "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like DA receptors. PLoS Negl Trop Dis 6 e1478 PMID: 22292096
Verma et al (2015) Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. J Neurosci 8 380 PMID: 25118166
Dierks et al (2010) The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Cancer Res 70 6193 PMID: 20670954
Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815
Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci 33 11206 PMID: 23825423
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