Piceatannol

Cat. No. 1554 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Inhibits TNF-induced NF-κB activation

化学名： 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol

纯度： ≥98% (HPLC)

引用文献 (8)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Piceatannol

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56^lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol (Cat. No. 1418) by cytochrome P450 1B1.

技术数据 for Piceatannol

分子量	244.25
公式	C₁₄H₁₂O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	10083-24-6
PubChem ID	667639
InChI Key	CDRPUGZCRXZLFL-OWOJBTEDSA-N
Smiles	OC1=CC(\C=C\C2=CC(O)=C(O)C=C2)=CC(O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Piceatannol

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	24.43	100
	DMSO	24.43	100

制备储备液 for Piceatannol

以下数据基于产品分子量 244.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.09 mL	20.47 mL	40.94 mL
5 mM	0.82 mL	4.09 mL	8.19 mL
10 mM	0.41 mL	2.05 mL	4.09 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

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产品说明书 for Piceatannol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Piceatannol

参考文献是支持产品生物活性的出版物。

Ashikawa et al (2002) Piceatannol inhibits TNF-induced NF-kB activation and NF-kB-mediated gene expression through suppression of IkBa kinase and p65 phosphorylation. J.Immunol. 169 6490 PMID: 12444159

Geahlen and McLaughlin (1989) Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochem.Biophys.Res.Commun. 165 241 PMID: 2590224

Oliver et al (1994) Inhibition of mast cell FceR1-mediated signalling and effector function by the syk-selective inhibitor, piceatannol. J.Biol.Chem. 269 29697 PMID: 7961959

Potter et al (2002) The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br.J.Cancer 86 774 PMID: 11875742

If you know of a relevant reference for Piceatannol, please let us know.

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关键词: Piceatannol, Piceatannol supplier, Syk, p56lck, kinase, inhibitors, inhibits, TNF-induced, NF-κB, NF-kappaB, NF-kB, activation, Kinases, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, Src, Kinase, NF-kB/IkB, 1554, Tocris Bioscience

8 篇 Piceatannol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Piceatannol 的部分引用包括：

Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci 33 11206 PMID: 23825423

Farrand et al (2013) Piceatannol enhances cisp. sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. J Biol Chem 288 23740 PMID: 23833193

Shin et al (2015) TH2 cells and their cytokines regulate formation and function of lymphatic vessels. Nat Commun 6 6196 PMID: 25648335

Bakema et al (2015) Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs. J Immunol 194 1856 PMID: 25582855

Meyer et al (2012) A "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like DA receptors. PLoS Negl Trop Dis 6 e1478 PMID: 22292096

Verma et al (2015) Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. J Neurosci 8 380 PMID: 25118166

Dierks et al (2010) The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Cancer Res 70 6193 PMID: 20670954

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Pathways for Piceatannol

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.