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PJ 34 hydrochloride

Cat. No. 3255 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent PARP inhibitor
化学名： N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PJ 34 hydrochloride

PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo. Displays protective effects against cisplatin-induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC50 values are 3.7 and 16 μM respectively).

化合物库 for PJ 34 hydrochloride

PJ 34 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PJ 34 hydrochloride

分子量 331.8
公式 C17H17N3O2.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 344458-15-7
PubChem ID 16760621
InChI Key RURAZZMDMNRXMI-UHFFFAOYSA-N
Smiles Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PJ 34 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 33.18 100
DMSO 33.18 100

制备储备液 for PJ 34 hydrochloride

以下数据基于产品分子量 331.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for PJ 34 hydrochloride

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for PJ 34 hydrochloride

参考文献是支持产品生物活性的出版物。

Abdelkarim et al (2001) Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int.J.Mol.Med. 7 255 PMID: 11179503

Gambi et al (2008) Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines. Biochem.Pharmacol. 75 2356 PMID: 18468580

Kim et al (2012) Poly(ADP-ribose) polymerase 1 activation is required for cisp. nephrotoxicity. Kidney Int. 82 193 PMID: 22437413

Antolin et al (2012) Identification of Pim kinases as novel targets for PJ34 with confounding effects in PARP biology. ACS Chem.Biol. 7 1962 PMID: 23025350

If you know of a relevant reference for PJ 34 hydrochloride, please let us know.

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关键词: PJ 34 hydrochloride, PJ 34 hydrochloride supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerases, PJ34, hydrochloride, Poly(ADP-ribose), Polymerase, 3255, Tocris Bioscience

1 篇 PJ 34 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PJ 34 hydrochloride 的部分引用包括：

Kirby et al (2012) Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939. Acta Crystallogr Sect F Struct Biol Cryst Commun 68 115 PMID: 22297980

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