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PK 44 phosphate

Cat. No. 4145 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4145 has been discontinued.

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说明： Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor
化学名： (3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for PK 44 phosphate

PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Improves glucose tolerance in a mouse oral glucose tolerance assay.

技术数据 for PK 44 phosphate

分子量 527.34
公式 C17H16F5N7O.H3PO4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1017682-66-4
PubChem ID 90488917
InChI Key IRIGBESJZBGJOS-DDWIOCJRSA-N
Smiles N[C@@H](CC(N4CC3=NN=C(C(F)(F)F)N3CC4)=O)CC2=NNC1=C(F)C(F)=CC=C12.OP(O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PK 44 phosphate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for PK 44 phosphate

参考文献是支持产品生物活性的出版物。

Tozer et al (2010) Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes. 32nd Annual National Medicinal Chemistry Symposium Poster 52

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关键词: PK 44 phosphate, PK 44 phosphate supplier, dipeptidyl, peptidase, IV, DPP-IV, potent, selective, inhibitors, inhibits, PK44, DPP4, Dipeptidyl, Peptidase, (DPP-IV), 4145, Tocris Bioscience

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