PLP (139-151)

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说明: Encephalitogenic myelin proteolipid fragment
别名: Proteolipid protein (139-151)
纯度: ≥95% (HPLC)
说明书
引用文献 (3)
评论

生物活性 for PLP (139-151)

PLP (139-151) is a synthetic myelin proteolipid protein (PLP) fragment. Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.

技术数据 for PLP (139-151)

分子量 1521.74
公式 C72H104N20O17
序列 HSLGKWLGHPDKF
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 122018-58-0
PubChem ID 16199055
InChI Key UQIBUOXNUPHALR-UVIWMAFZSA-N
Smiles [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PLP (139-151)

溶解性 Soluble to 2 mg/ml in water

产品说明书 for PLP (139-151)

分析证书/产品说明书
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参考文献 for PLP (139-151)

参考文献是支持产品生物活性的出版物。

Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 142 1523 PMID: 2465343

Sobel et al (1990) Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. J.Neuropathol.Exp.Neurol. 49 468 PMID: 2273404

Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 59 305 PMID: 1716908


If you know of a relevant reference for PLP (139-151), please let us know.

关键词: PLP (139-151), PLP (139-151) supplier, Encephalitogenic, myelin, proteolipid, fragment, Neuronal, Metabolism, multiple, sclerosis, encephalomyelitis, EAE, Proteolipid, protein, (139-151), 2567, Tocris Bioscience

3 篇 PLP (139-151) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PLP (139-151) 的部分引用包括:

Arima et al (2015) A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model. Elife 4 PMID: 26193120

Jana et al (2012) Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β. J Biol Chem 287 34134 PMID: 22879602

Mondal et al (2012) Regulation of encephalitogenicity of neuroantigen-primed T cells by nitric oxide: Implications for multiple sclerosis. J Clin Cell Immunol 3 124 PMID: 23275862


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