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Submit ReviewPLP (139-151) is a synthetic myelin proteolipid protein (PLP) fragment. Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.
分子量 | 1521.74 |
公式 | C72H104N20O17 |
序列 | HSLGKWLGHPDKF |
储存 | Store at -20°C |
纯度 | ≥95% (HPLC) |
CAS Number | 122018-58-0 |
PubChem ID | 16199055 |
InChI Key | UQIBUOXNUPHALR-UVIWMAFZSA-N |
Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性 | Soluble to 2 mg/ml in water |
参考文献是支持产品生物活性的出版物。
Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 142 1523 PMID: 2465343
Sobel et al (1990) Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. J.Neuropathol.Exp.Neurol. 49 468 PMID: 2273404
Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 59 305 PMID: 1716908
If you know of a relevant reference for PLP (139-151), please let us know.
关键词: PLP (139-151), PLP (139-151) supplier, Encephalitogenic, myelin, proteolipid, fragment, Neuronal, Metabolism, multiple, sclerosis, encephalomyelitis, EAE, Proteolipid, protein, (139-151), 2567, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 PLP (139-151) 的部分引用包括:
Arima et al (2015) A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model. Elife 4 PMID: 26193120
Jana et al (2012) Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β. J Biol Chem 287 34134 PMID: 22879602
Mondal et al (2012) Regulation of encephalitogenicity of neuroantigen-primed T cells by nitric oxide: Implications for multiple sclerosis. J Clin Cell Immunol 3 124 PMID: 23275862
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