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说明： Selective α7 nAChR agonist
化学名： N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide
纯度： ≥98% (HPLC)
生物活性 for PNU 282987
PNU 282987 is a highly selective α7 nAChR agonist (Ki = 26 nM) displaying negligible blockade of α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM). Found to be inactive against a panel of 32 receptors at 1 μM, except 5-HT3 receptors (Ki = 930 nM).
化合物库 for PNU 282987
PNU 282987 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for PNU 282987
| 分子量 | 264.75 |
| 公式 | C14H17ClN2O |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 711085-63-1 |
| PubChem ID | 9795278 |
| InChI Key | WECKJONDRAUFDD-ZDUSSCGKSA-N |
| Smiles | O=C(C2=CC=C(Cl)C=C2)N[C@@H]1C3CCN(CC3)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PNU 282987
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. HCl | 26.48 | 100 | |
| DMSO | 26.48 | 100 |
制备储备液 for PNU 282987
以下数据基于产品分子量 264.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.78 mL | 18.89 mL | 37.77 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.55 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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产品说明书 for PNU 282987
参考文献 for PNU 282987
参考文献是支持产品生物活性的出版物。
Bodnar et al (2005) Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors. J.Med.Chem. 48 905 PMID: 15715459
Hajós et al (2005) The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthe J.Pharmacol.Exp.Ther. 312 1213 PMID: 15523001
If you know of a relevant reference for PNU 282987, please let us know.
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关键词: PNU 282987, PNU 282987 supplier, Selective, α7, alpha7, a7, nAChR, agonists, Nicotinic, Receptors, Acetylcholine, PNU282987, (a7), 2303, Tocris Bioscience
3 篇 PNU 282987 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PNU 282987 的部分引用包括：
Zhong et al (2013) Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. Elife 8 e82719 PMID: 24349346
Pandya and Yakel (2013) Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT?a receptor antagonist. Neuropharmacology 70 35 PMID: 23321689
Wang et al (2012) Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci 32 9773 PMID: 22815492
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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