PNU 37883 hydrochloride

Name: PNU 37883 hydrochloride
Brand: Tocris Bioscience
SKU: 2095
Rating: 4 (1 reviews)

Cat. No. 2095 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Vascular K_ir6 (K_ATP) channel blocker

化学名： N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PNU 37883 hydrochloride

PNU 37883 hydrochloride is a novel antagonist selective for the vascular form of K_ir6 (K_ATP) channel; inhibits K_ir6 currents in isolated mesenteric artery smooth muscle cells (K_d = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

化合物库 for PNU 37883 hydrochloride

PNU 37883 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PNU 37883 hydrochloride

分子量	381.98
公式	C₂₁H₃₅N₃O.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	57568-80-6
PubChem ID	64392
InChI Key	FZALCKUJYZCDOX-UHFFFAOYSA-N
Smiles	C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PNU 37883 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	9.55	25
	ethanol	38.2	100

制备储备液 for PNU 37883 hydrochloride

以下数据基于产品分子量 381.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.09 mL	26.18 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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产品说明书 for PNU 37883 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PNU 37883 hydrochloride

参考文献是支持产品生物活性的出版物。

Humphrey and Ludens (1998) K_ATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894 PMID: 9641474

Cui et al (2003) Different molecular sites of action for the K_ATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122 PMID: 12746230

Kovalev et al (2004) Molecular analysis of the subtype-selective inhibition of cloned K_ATP channels by PNU-37883A. Br.J.Pharmacol. 141 867 PMID: 14757705

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