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说明： β-catenin binder; inhibits Wnt signaling
化学名： 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
纯度： ≥99% (HPLC)
生物活性 for PNU 74654
Binds to β-catenin (KD = 450 nM). Inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway. Promotes neural differentiation of hPSCs as part of a chemical cocktail.
化合物库 for PNU 74654
PNU 74654 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for PNU 74654
| 分子量 | 320.34 |
| 公式 | C19H16N2O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 113906-27-7 |
| PubChem ID | 9836739 |
| InChI Key | JJEDWBQZCRESJL-DEDYPNTBSA-N |
| Smiles | O=C(N/N=C/C2=CC=C(C)O2)C1=C(OC3=CC=CC=C3)C=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for PNU 74654
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 32.03 | 100 |
制备储备液 for PNU 74654
以下数据基于产品分子量 320.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.61 mL | 31.22 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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产品说明书 for PNU 74654
参考文献 for PNU 74654
参考文献是支持产品生物活性的出版物。
Trosset et al (2006) Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins 64 60 PMID: 16568448
Wells and McClendon (2007) Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450 1001 PMID: 18075579
Chen et al (2019) Chemically defined neural conversion of human pluripotent stem cells. Methods Mol.Biol. 1919 59 PMID: 30656621
If you know of a relevant reference for PNU 74654, please let us know.
关键词: PNU 74654, PNU 74654 supplier, PNU74654, beta-catenin, b-catenin, β-catenin, binders, wnt, signalling, signaling, neural, stem, cell, differentiation, Beta-catenin, Neural, Stem, Cells, 3534, Tocris Bioscience
9 篇 PNU 74654 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PNU 74654 的部分引用包括：
Chen et al (2019) Chemically defined neural conversion of human pluripotent stem cells. Methods Mol.Biol. 1919 59 PMID: 30656621
Liao et al (2015) Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells. Nature 47 469 PMID: 25822089
Tsankov et al (2015) Transcription factor binding dynamics during human ES cell differentiation. Stem Cells Int 518 344 PMID: 25693565
Yang et al (2015) Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors. Cell Reprogram 2015 270428 PMID: 26089912
Margaret E et al (2023) FSCN1 as a new druggable target in adrenocortical carcinoma. Int J Cancer 153 210-223 PMID: 36971100
Corritore et al (2014) β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion. Ann Neurol 16 456 PMID: 25437872
Baril et al (2013) Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. PLoS Pathog 9 e1003416 PMID: 23785285
Juan C et al (2021) α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss. J Neurosci 41 2264-2273 PMID: 33483428
Stephen J et al (2021) Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. Genes Dev 35 1527-1547 PMID: 34711655
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Neural Induction Conditions.
By
Anonymous on 03/22/2020
分析类型： In Vitro
种属： Human
细胞系/组织： H9
2 μM PNU-74654
Pathways for PNU 74654
