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PPTN hydrochloride

Cat. No. 4862 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity and selective P2Y14 antagonist
化学名： 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PPTN hydrochloride

PPTN hydrochloride is a high affinity and selective P2Y14 antagonist (KB = 434 pM), which exhibits >10,000-fold selectivity for P2Y14 over other P2Y receptors. PPTN inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo, and also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.

External Portal Information for PPTN hydrochloride

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PPTN is reviewed.

化合物库 for PPTN hydrochloride

PPTN hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PPTN hydrochloride

分子量 511.96
公式 C29H24F3NO2.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1992047-65-0
PubChem ID 121513852
InChI Key FKMVYPCBLWYNAV-UHFFFAOYSA-N
Smiles FC(F)(F)C(C=C4)=CC=C4C1=CC=C(C(C3=CC=C(C5CCNCC5)C=C3)=CC(C(O)=O)=C2)C2=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PPTN hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.2 100
ethanol 10.24 20

制备储备液 for PPTN hydrochloride

以下数据基于产品分子量 511.96。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.77 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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产品说明书 for PPTN hydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for PPTN hydrochloride

参考文献是支持产品生物活性的出版物。

Gao et al (2013) The role of P2Y14 and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 9 31 PMID: 22825617

Alsaqati et al (2014) Novel vasocontractile role of the P2Y14 receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br.J.Pharmacol. 171 701 PMID: 24138077

Barrett et al (2013) A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol.Pharmacol. 84 41 PMID: 23592514

If you know of a relevant reference for PPTN hydrochloride, please let us know.

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关键词: PPTN hydrochloride, PPTN hydrochloride supplier, 1160271-30-6, high, affinity, selective, P2Y14, purinergics, receptor, antagonists, antagonises, inhibitors, inhibits, Purinergic, P2Y, Receptors, 4862, Tocris Bioscience

2 篇 PPTN hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PPTN hydrochloride 的部分引用包括：

Tilat A et al (2022) P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis. Elife 11 PMID: 35311647

Dennis et al (2020) Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice. J Clin Invest 130 3734-3749 PMID: 32287042

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PPTN hydrochloride 的评论

平均评分: 4 (Based on 1 Review.)

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P2Y14 antagonist.
By Anonymous on 09/20/2018
分析类型： Ex Vivo
种属： Mouse

Incubation and during agonist treatment

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