PRIMA-1^MET

Cat. No. 3710 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Restores mutant p53 activity

别名： APR-246

化学名： 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

纯度： ≥98% (HPLC)

引用文献 (3)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PRIMA-1^MET

PRIMA-1^MET is a methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.

化合物库 for PRIMA-1^MET

PRIMA-1MET is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PRIMA-1^MET

分子量	199.25
公式	C₁₀H₁₇NO₃
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	5291-32-7
PubChem ID	52918385
InChI Key	BGBNULCRKBVAKL-UHFFFAOYSA-N
Smiles	OCC1(COC)C(C2CCN1CC2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PRIMA-1^MET

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	19.93	100
	DMSO	19.93	100

制备储备液 for PRIMA-1^MET

以下数据基于产品分子量 199.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	5.02 mL	25.09 mL	50.19 mL
5 mM	1 mL	5.02 mL	10.04 mL
10 mM	0.5 mL	2.51 mL	5.02 mL
50 mM	0.1 mL	0.5 mL	1 mL

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产品说明书 for PRIMA-1^MET

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PRIMA-1^MET

参考文献是支持产品生物活性的出版物。

Bykov et al (2005) PRIMA-1^MET synergizes with cisp. to induce tumor cell apoptosis. Oncogene 24 3484 PMID: 15735745

Shen et al (2008) PRIMA-1^MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene 27 6571 PMID: 18663359

Stuber et al (2009) PRIMA-1^MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol.Cancer 8 23 PMID: 19323829

If you know of a relevant reference for PRIMA-1^MET, please let us know.

按标靶查看相关产品

关键词: PRIMA-1MET, PRIMA-1MET supplier, Restores, mutant, p53, activity, transcription, factors, APR-246, 3710, Tocris Bioscience

3 篇 PRIMA-1^MET 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PRIMA-1^MET 的部分引用包括：

Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703

Kunle O et al (2022) Estrogen Receptor-Beta2 (ERβ2)-Mutant p53-FOXM1 Axis: A Novel Driver of Proliferation, Chemoresistance, and Disease Progression in High Grade Serous Ovarian Cancer (HGSOC). Cancers (Basel) 14 PMID: 35267428

Katja et al (2022) Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype. Mol Cancer Ther 21 1236-1245 PMID: 35364610

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

Cell Cycle and Mitosis
DNA Damage Repair
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Ubiquitin Proteasome Pathway
Chemotherapy Targets

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for PRIMA-1^MET

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.