Prion Protein 106-126 (human)

Name: Prion Protein 106-126 (human)
Brand: Tocris Bioscience
SKU: 3491

Cat. No. 3491 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3491 has been discontinued.

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说明： Prion protein fragment

说明书

引用文献 (1)

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for Prion Protein 106-126 (human)

Prion Protein 106-126 (human) is a prion peptide fragment that shares many physiochemical features with PrP^Sc. Exhibits neurotoxicity caused by amplification of PrP^C-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms β-sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases in vitro.

技术数据 for Prion Protein 106-126 (human)

分子量	1912.26
公式	C₈₀H₁₃₈N₂₆O₂₄S₂
序列	KTNMKHMAGAAAAGAVVGGLG
储存	Desiccate at -20°C
CAS Number	148439-49-0
PubChem ID	16135249
InChI Key	XPZWWTIIKSODDO-MBNDGZRNSA-N
Smiles	[H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Prion Protein 106-126 (human)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Prion Protein 106-126 (human)

参考文献是支持产品生物活性的出版物。

Forloni et al (1993) Neurotoxicity of a prion protein fragment. Nature 362 543 PMID: 8464494

Pietri et al (2006) Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. J.Biol.Chem. 281 28470 PMID: 16864581

Bai et al (2008) p75NTR activation of NF-κB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells. Neurosci.Res. 62 9 PMID: 18602709

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关键词: Prion Protein 106-126 (human), Prion Protein 106-126 (human) supplier, Prion, protein, fragment, PrPSc, Antiprion, Neuronal, Metabolism, Protein, 3491, Tocris Bioscience

1 篇 Prion Protein 106-126 (human) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Prion Protein 106-126 (human) 的部分引用包括：

Domizio et al (2012) Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid. J Biol Chem 287 736 PMID: 22102410