Psoralen-triethylene glycol azide

Cat. No. 6862 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： RNA conformation probe; reagent for COMRADES RNA platform

别名： psoralen-triethylene glycol azide

化学名： 3-(13-Azido-5,8,11-trioxa-2-azatridec-1-yl)-2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-one

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Psoralen-triethylene glycol azide

Psoralen TEG Azide is used to probe RNA structure and conformation in live cells, using the cross-linking of matched RNAs and deep sequencing or COMRADES method. Psoralen crosslinks the RNA and the azide enables subsequent click reaction with biotin. The COMRADES method has been used to determine the architecture of the Zika virus RNA genome inside cells, and identified multiple site-specific interactions with human noncoding RNAs. It has also been used to map RNA-RNA interactions along the SARS-CoV-2 genome and subgenomes inside cells. Psoralen TEG Azide is cell permeable. For detailed methods please see references section below.

技术数据 for Psoralen-triethylene glycol azide

分子量	458.52
公式	C₂₃H₃₀N₄O₆
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1352815-11-2
InChI Key	LVWBLKATXVGKHP-UHFFFAOYSA-N
Smiles	O=C(C=C1C)OC2=C1C=C(C(CNCCOCCOCCOCCN=[N+]=[N-])=C(C)O3)C3=C2C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Psoralen-triethylene glycol azide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	45.85	100
	ethanol	22.93	50

制备储备液 for Psoralen-triethylene glycol azide

以下数据基于产品分子量 458.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.9 mL	21.81 mL
5 mM	0.44 mL	2.18 mL	4.36 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for Psoralen-triethylene glycol azide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Psoralen-triethylene glycol azide

参考文献是支持产品生物活性的出版物。

Ziv et al (2020) The short- and long-range RNA-RNA interactome of SARS-CoV-2. Mol. Cell 80 1067 PMID: 33259809

Ziv et al (2018) COMRADES determines in vivo RNA structures and interactions. Nat. Methods 15 785 PMID: 30202058

If you know of a relevant reference for Psoralen-triethylene glycol azide, please let us know.

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