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R-BC154

Cat. No. 6048 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6048 has been discontinued.

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说明： High affinity fluorescent α4β1/α9β1 inhibitor; mobilizes HSCs
化学名： (4R)-4-[4-[[[[4-[3,6-Bis(diethylamino)xanthylium-9-yl]-3-sulfophenyl]sulfonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1-(phenylsulfonyl)-L-prolyl-O-(1-pyrrolidinyl)-L-tyrosine acetate
纯度： ≥97% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for R-BC154

R-BC154 is a high affinity fluorescent α4β1/α9β1 inhibitor (Kd values are 12.7 and 38 nM, respectively); fluorescent version of BOP (Cat.No. 6047). Rapidly and preferentially mobilizes HSCs and progenitors in vivo. Excitation maximum, 561 nm; emissiosn maximum, 585 nm.

技术数据 for R-BC154

分子量 1212.37
公式 C55H61N9O13S3.CH3CO2H
储存 Store at -20°C
纯度 ≥97% (HPLC)
PubChem ID 131648245
InChI Key HZQNIDGYMDDNNP-MOVBADFXSA-N
Smiles CCN(C1=CC2=[O+]C3=C(C(C4=C(S([O-])(=O)=O)C=C(S(=O)(NCC5=CN([C@@H]6C[C@@H](C(N[C@H](C(O)=O)CC7=CC=C(C=C7)OC(N8CCCC8)=O)=O)N(S(=O)(C9=CC=CC=C9)=O)C6)N=N5)=O)C=C4)=C2C=C1)C=CC(N(CC)CC)=C3)CC.CC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for R-BC154

参考文献是支持产品生物活性的出版物。

Cao et al (2014) Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 12 965 PMID: 24363056

Cao et al (2016) Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 7 11007 PMID: 26975966

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

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