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(R)-MG 132

Cat. No. 6033 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent 20S proteasome inhibitor
化学名： N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-D-leucinamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (R)-MG 132

(R)-MG 132 is a potent 20S proteasome inhibitor (IC50 = 0.22 nM). Exhibits cytostatic and cytotoxic effects in tumor cells in vitro.

技术数据 for (R)-MG 132

分子量 475.63
公式 C26H41N3O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1211877-36-9
PubChem ID 45103781
InChI Key TZYWCYJVHRLUCT-ZRBLBEILSA-N
Smiles CC(C[C@@H](C=O)NC([C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)CC(C)C)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R)-MG 132

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.56 100
ethanol 9.51 20

制备储备液 for (R)-MG 132

以下数据基于产品分子量 475.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.1 mL 10.51 mL 21.02 mL
5 mM 0.42 mL 2.1 mL 4.2 mL
10 mM 0.21 mL 1.05 mL 2.1 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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参考文献 for (R)-MG 132

参考文献是支持产品生物活性的出版物。

Mroczkiewicz et al (2010) Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J.Med.Chem. 53 1509 PMID: 20112914

If you know of a relevant reference for (R)-MG 132, please let us know.

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关键词: (R)-MG 132, (R)-MG 132 supplier, (R)-MG132, 20S, proteasome, inhibitors, inhibits, potent, Proteasome, 6033, Tocris Bioscience

3 篇 (R)-MG 132 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R)-MG 132 的部分引用包括：

C David et al (2019) Identification of Novel RAS Signaling Therapeutic Vulnerabilities in Diffuse Intrinsic Pontine Gliomas. Cancer Res 79 4026-4041 PMID: 31201162

Armando A et al (2022) Calcineurin Controls Cellular Prion Protein Expression in Mouse Astrocytes. Cells 11 PMID: 35203261

Eleonora et al (2020) Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation. Int J Mol Sci 21 PMID: 32210081

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia