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(R)-ZINC 3573

Cat. No. 6351 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： MRGPRX2 agonist
化学名： (3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (R)-ZINC 3573

(R)-ZINC 3573 is a Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC50 = 0.74 μM), which displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. (R)-ZINC 3573 induces intracellular calcium release and degranulation in LAD2 mast cells in vitro.

Negative control (S)-ZINC 3573 (Cat. No. 6352) also available.

External Portal Information for (R)-ZINC 3573

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of (R)-ZINC 3573 is reviewed on chemicalprobes.org and the SGC website.

化合物库 for (R)-ZINC 3573

(R)-ZINC 3573 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for (R)-ZINC 3573

分子量 307.4
公式 C18H21N5
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 2089389-15-9
PubChem ID 95882507
InChI Key XKBSPAZCFAIBJL-OAHLLOKOSA-N
Smiles CN([C@H]1CN(C2=CC(C3=CC=CC=C3)=NC4=CC=NN24)CC1)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R)-ZINC 3573

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 30.74 100
DMSO 30.74 100

制备储备液 for (R)-ZINC 3573

以下数据基于产品分子量 307.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.53 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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参考文献 for (R)-ZINC 3573

参考文献是支持产品生物活性的出版物。

Lansu et al (2017) In silico design of novel probes for the atypical opioid receptor MRGPRX2. Nat.Chem.Biol. 13 529 PMID: 28288109

If you know of a relevant reference for (R)-ZINC 3573, please let us know.

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关键词: (R)-ZINC 3573, (R)-ZINC 3573 supplier, (R)-ZINC3573, ZINC3573, mas, related, g, protein, coupled, receptor, X2, agonists, MRGPRX2, mast, cell, degranulation, agonism, Mas-related, G, Protein-Coupled, Receptors, 6351, Tocris Bioscience

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