主页 / 细胞生物学 / Regulated Cell Death / Apoptosis / 14.3.3 Proteins / 14.3.3 Protein Inhibitors / R18

R18

Cat. No. 2144 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Inhibitor of 14.3.3 proteins
纯度： ≥95% (HPLC)
说明书
引用文献
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文献 (2)
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for R18

R18 is an antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.

技术数据 for R18

分子量 2309.69
公式 C101H157N27O29S3
序列 PHCVPRDLSWLDLEANMCLP
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 211364-78-2
PubChem ID 16138697
InChI Key YSKZRNFKZLWXRG-ZHTKBQOPSA-N
Smiles [H]N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for R18

溶解性 Soluble to 1 mg/ml in water

产品说明书 for R18

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参考文献 for R18

参考文献是支持产品生物活性的出版物。

Wang et al (1999) Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display. Biochemistry 38 12499 PMID: 10493820

Masters and Fu (2001) 14.3.3 proteins mediate an essential anti-apoptotic signal. J.Biol.Chem. 276 45193 PMID: 11577088

Masters et al (2002) Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions 30 360

If you know of a relevant reference for R18, please let us know.

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关键词: R18, R18 supplier, inhibitors, inhibits, 1433, proteins, induces, apoptosis, 14-3-3, 14.3.3, Proteins, 2144, Tocris Bioscience

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