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说明： Nrf2 activator; inhibits Nrf2/Keap1 interaction
化学名： (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for RA 839
RA 839 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). Suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory.
化合物库 for RA 839
RA 839 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for RA 839
| 分子量 | 452.57 |
| 公式 | C25H28N2O4S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1832713-02-6 |
| PubChem ID | 91971266 |
| InChI Key | BVYWIQHJXAEJOD-IBGZPJMESA-N |
| Smiles | CC1=C(C)C=C(C)C(C)=C1S(=O)(NC2=C(C=CC=C3)C3=C(N4C[C@@H](C(O)=O)CC4)C=C2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for RA 839
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 45.26 | 100 |
制备储备液 for RA 839
以下数据基于产品分子量 452.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.05 mL | 22.1 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for RA 839
参考文献 for RA 839
参考文献是支持产品生物活性的出版物。
Winkel et al (2015) Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. J.Biol.Chem. 290 28446 PMID: 26459563
If you know of a relevant reference for RA 839, please let us know.
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关键词: RA 839, RA 839 supplier, RA839, Nrf2, activators, activates, NFE2L2, erythroid-derived, nuclear, factors, Keap1, interations, inhibitors, inhibits, inducible, nitric, oxide, synthases, oxides, anti-inflammatory, 5707, Tocris Bioscience
2 篇 RA 839 的引用文献
引用文献是使用了 Tocris 产品的出版物。 RA 839 的部分引用包括：
Vladimir et al (2021) A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy. Redox Biol 48 102186 PMID: 34801863
Rakesh et al (2020) Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units. Oxid Med Cell Longev 2020 7289120 PMID: 32322337
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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