主页 / 药理学 / Enzymes / Proteases / Angiotensin-Converting Enzyme / Angiotensin-Converting Enzyme Inhibitors / Ramipril

Ramipril

Cat. No. 5250 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5250 has been discontinued.

View all Angiotensin-Converting Enzyme products.
说明： Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor
化学名： (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Ramipril

Ramipril is a non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). Prodrug which is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Exhibits antihypertensive effects.

化合物库 for Ramipril

Ramipril is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Ramipril

分子量 416.51
公式 C23H32N2O5
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 87333-19-5
PubChem ID 5362129
InChI Key HDACQVRGBOVJII-JBDAPHQKSA-N
Smiles [H][C@@]12CCC[C@@]([H])1N(C([C@H](C)N[C@H]([C@@](OCC)=O)CCC3=CC=CC=C3)=O)[C@H]([C@@](O)=O)C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Ramipril

参考文献是支持产品生物活性的出版物。

Tian et al (2014) Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKK beta /AMPK and heme oxygenase-1 activation. J.Pharmacol.Exp.Ther. 350 5 PMID: 24741076

Levitt et al (2006) Human physiologically based pharmacokinetic model for ACE inhibitors: ram. and ramiprilat. BMC Clin. Pharmacol. 6 1 PMID: 16398929

Stevens et al (1988) Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp.Biochem.Physiol C. 91 493 PMID: 2905962

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Angiotensin-Converting Enzyme Inhibitors

关键词: Ramipril, Ramipril supplier, Non-peptide, competitive, angiotensin, converting, enzyme, ACE, inhibitors, inhibits, antihypertensive, Angiotensin-Converting, Enzyme, 5250, Tocris Bioscience

篇 Ramipril 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Ramipril 的引用文献。

Ramipril 的评论

目前没有该产品的评论。 Be the first to review Ramipril and earn rewards!

Have you used Ramipril?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review